Sorting Nexin 3 抗体 (Internal Region)
Quick Overview for Sorting Nexin 3 抗体 (Internal Region) (ABIN6257497)
抗原
See all Sorting Nexin 3 (SNX3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- SNX3 Antibody detects endogenous levels of total SNX3.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SNX3, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Sorting Nexin 3 (SNX3) antibody
SNX3 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 3 (SNX3) (AA 1-113) antibodySNX3 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3D7 unconjugated
anti-Sorting Nexin 3 (SNX3) (AA 78-105) antibodySNX3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB37070 unconjugated
anti-Sorting Nexin 3 (SNX3) antibody (FITC)SNX3 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-Sorting Nexin 3 (SNX3) (AA 3-162) antibodySNX3 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 3 (SNX3) antibody (Biotin)SNX3 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal Biotin
anti-Sorting Nexin 3 (SNX3) antibody (HRP)SNX3 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal HRP
anti-Sorting Nexin 3 (SNX3) (AA 1-162) antibodySNX3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Sorting Nexin 3 (SNX3)
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别名
- SNX3
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背景
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Description: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes, the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).
Gene: SNX3
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分子量
- 18 kDa
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基因ID
- 8724
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UniProt
- O60493
抗原
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