RPS3 抗体 (Internal Region)
Quick Overview for RPS3 抗体 (Internal Region) (ABIN6257472)
抗原
See all RPS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- RPS3 Antibody detects endogenous levels of total RPS3.
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预测反应
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human RPS3, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Ribosomal Protein S3 (RPS3) (AA 1-243) antibody
RPS3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) antibodyRPS3 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) antibodyRPS3 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) (AA 144-243) antibodyRPS3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Ribosomal Protein S3 (RPS3) antibodyRPS3 适用: 人 WB, IHC, ELISA, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) antibodyRPS3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) (AA 101-200) antibodyRPS3 适用: 人, 小鼠, 非洲爪蟾 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) (C-Term) antibodyRPS3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S3 (RPS3) antibodyRPS3 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal RP159-1 unconjugated
anti-Ribosomal Protein S3 (RPS3) (C-Term) antibodyRPS3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- RPS3 (Ribosomal Protein S3 (RPS3))
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别名
- RPS3
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背景
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Description: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).
Gene: RPS3
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分子量
- 30 kDa
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基因ID
- 6188
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UniProt
- P23396
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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