NDFIP2 抗体 (Internal Region)
Quick Overview for NDFIP2 抗体 (Internal Region) (ABIN6257381)
抗原
See all NDFIP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- NDFIP2 Antibody detects endogenous levels of total NDFIP2.
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预测反应
- Pig,Bovine,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human NDFIP2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 1-242) antibody
NDFIP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C7 unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 152-201) antibodyNDFIP2 适用: 人, 小鼠, Cow, 犬, 马, 大鼠, 斑马鱼, 豚鼠, Pig, Bat, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 1-242) antibodyNDFIP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 251-300) antibodyNDFIP2 适用: 人, 小鼠, Cow, 犬, 马, 大鼠, 斑马鱼, Pig, 兔, Bat, 小鸡, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (Middle Region) antibodyNDFIP2 适用: 人, 小鼠, Cow, 犬, 马, 大鼠, 斑马鱼, 豚鼠, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (N-Term) antibodyNDFIP2 适用: 人, 小鼠, Cow, 犬, 马, 大鼠, 斑马鱼, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- NDFIP2 (Nedd4 Family Interacting Protein 2 (NDFIP2))
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别名
- NDFIP2
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背景
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Description: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).
Gene: NDFIP2
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分子量
- 36 kDa
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基因ID
- 54602
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UniProt
- Q9NV92
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途径
- Negative Regulation of Transporter Activity, SARS-CoV-2 Protein Interactome
抗原
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