Cytochrome P450 3A4, 3A5 抗体
Quick Overview for Cytochrome P450 3A4, 3A5 抗体 (ABIN6257328)
抗原
适用
宿主
克隆类型
标记
应用范围
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特异性
- Cytochrome P450 3A4/5 Antibody detects endogenous levels of total Cytochrome P450 3A4/5
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide
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亚型
- IgG
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anti-Cytochrome P450 3A4, 3A5 (Center) antibody
适用: 人 WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450 3A4, 3A5 (AA 251-300) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500~1:1000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- Cytochrome P450 3A4, 3A5
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别名
- Cytochrome P450 3A4/5
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背景
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Description: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
Gene: CYP3A4
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分子量
- 57 kDa
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基因ID
- 1576
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UniProt
- P08684, P20815
抗原
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