GPS2 抗体 (N-Term)
Quick Overview for GPS2 抗体 (N-Term) (ABIN6257198)
抗原
See all GPS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- GPS2 Antibody detects endogenous levels of total GPS2.
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预测反应
- Pig,Bovine,Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human GPS2, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-G Protein Pathway Suppressor 2 (GPS2) (AA 228-327) antibody
GPS2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-G Protein Pathway Suppressor 2 (GPS2) (AA 1-100) antibodyGPS2 适用: 人, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-G Protein Pathway Suppressor 2 (GPS2) (N-Term) antibodyGPS2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein Pathway Suppressor 2 (GPS2) (AA 1-327) antibodyGPS2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein Pathway Suppressor 2 (GPS2) (AA 228-327) antibodyGPS2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-G Protein Pathway Suppressor 2 (GPS2) (N-Term) antibodyGPS2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein Pathway Suppressor 2 (GPS2) (AA 1-327) antibodyGPS2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- GPS2 (G Protein Pathway Suppressor 2 (GPS2))
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别名
- GPS2
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背景
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Description: Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway, acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081).
Gene: GPS2
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分子量
- 40 kDa
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基因ID
- 2874
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UniProt
- Q13227
抗原
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