E2F7 抗体
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北京 101111
Quick Overview for E2F7 抗体 (ABIN6257151)
抗原
See all E2F7 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- E2F7 antibody detects endogenous levels of total E2F7
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交叉反应
- 人
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide
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亚型
- IgG
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anti-E2F Transcription Factor 7 (E2F7) (N-Term) antibody
E2F7 适用: 人, 小鼠, 犬, 大鼠, Cow, 马, 兔, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) antibodyE2F7 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (N-Term) antibodyE2F7 适用: 人, 小鼠, 犬, 大鼠, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (Internal Region) antibodyVerified E2F7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (AA 108-157) antibodyE2F7 适用: 小鼠, 大鼠, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (N-Term) antibodyE2F7 适用: 人, 小鼠, 犬, 大鼠, Cow, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000 IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- E2F7 (E2F Transcription Factor 7 (E2F7))
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别名
- E2F7
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背景
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Description: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
Gene: E2F7
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分子量
- 99 kDa
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基因ID
- 144455
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UniProt
- Q96AV8
抗原
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