Cyclin T2 抗体 (Internal Region)
Quick Overview for Cyclin T2 抗体 (Internal Region) (ABIN6257122)
抗原
See all Cyclin T2 (CCNT2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- CCNT2 Antibody detects endogenous levels of total CCNT2.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Cyclin T2 (CCNT2) (C-Term) antibody
CCNT2 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin T2 (CCNT2) (AA 264-370) antibodyCCNT2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H3 unconjugated
anti-Cyclin T2 (CCNT2) antibodyCCNT2 适用: 人 WB, DB 宿主: 小鼠 Monoclonal 2128C1a unconjugated
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应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- Cyclin T2 (CCNT2)
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别名
- CCNT2
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背景
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Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).
Gene: CCNT2
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分子量
- 81kDa
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基因ID
- 905
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UniProt
- O60583
抗原
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