Cullin 4A 抗体 (N-Term)
Quick Overview for Cullin 4A 抗体 (N-Term) (ABIN6257115)
抗原
See all Cullin 4A (CUL4A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- CUL4A Antibody detects endogenous levels of total CUL4A.
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预测反应
- Pig,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CUL4A, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Cullin 4A (CUL4A) (AA 1-759) antibody
CUL4A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-100) antibodyCUL4A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-100) antibodyCUL4A 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3H3 unconjugated
anti-Cullin 4A (CUL4A) (AA 1-759) antibodyCUL4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 31-60), (N-Term) antibodyCUL4A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB33954 unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (Middle Region) antibodyCUL4A 适用: 人, 小鼠, 大鼠, 马, 兔, 犬, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-61) antibodyCUL4A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- Cullin 4A (CUL4A)
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别名
- CUL4A
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背景
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Description: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
Gene: CUL4A
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分子量
- 88 kDa
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基因ID
- 8451
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UniProt
- Q13619
抗原
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