CPEB1 抗体 (Internal Region)
Our Local Distributor
北京 101111
Quick Overview for CPEB1 抗体 (Internal Region) (ABIN6257072)
抗原
See all CPEB1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
原理
- CPEB1 Antibody
-
特异性
- CPEB1 Antibody detects endogenous levels of total CPEB1.
-
预测反应
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human CPEB1, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 1-486) antibody
CPEB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) antibodyCPEB1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3495 unconjugated Recombinant Antibody
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 311-561) antibodyCPEB1 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (C-Term) antibodyVerified CPEB1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (C-Term) antibodyCPEB1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 1-486) antibodyCPEB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))
-
别名
- CPEB1
-
背景
-
Description: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).
Gene: CPEB1
-
分子量
- 63 kDa
-
基因ID
- 64506
-
UniProt
- Q9BZB8
-
途径
- Synaptic Membrane
抗原
-
