CPEB1 抗体 (Internal Region)
Quick Overview for CPEB1 抗体 (Internal Region) (ABIN6257072)
抗原
See all CPEB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- CPEB1 Antibody detects endogenous levels of total CPEB1.
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预测反应
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CPEB1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 1-486) antibody
CPEB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 311-561) antibodyCPEB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (C-Term) antibodyVerified CPEB1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 1-486) antibodyCPEB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 282-561) antibodyCPEB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (C-Term) antibodyCPEB1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))
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别名
- CPEB1
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背景
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Description: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).
Gene: CPEB1
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分子量
- 63 kDa
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基因ID
- 64506
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UniProt
- Q9BZB8
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途径
- Synaptic Membrane
抗原
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