CDK5RAP3 抗体
Quick Overview for CDK5RAP3 抗体 (ABIN6257054)
抗原
See all CDK5RAP3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- CDK5RAP3 Antibody detects endogenous levels of total CDK5RAP3
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide
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亚型
- IgG
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anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) (AA 1-506) antibody
CDK5RAP3 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) antibodyCDK5RAP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) (AA 42-292), (Regulatory Subunit) antibodyCDK5RAP3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) (AA 341-390) antibodyCDK5RAP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) (AA 1-300) antibodyCDK5RAP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) (AA 1-300) antibodyCDK5RAP3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) (Center) antibodyCDK5RAP3 适用: 人, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500~1:1000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))
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别名
- CDK5RAP3
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背景
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Description: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
Gene: CDK5RAP3
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分子量
- 60 kDa
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基因ID
- 80279
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UniProt
- Q96JB5
抗原
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