CCBP2 抗体 (C-Term)
Quick Overview for CCBP2 抗体 (C-Term) (ABIN6257026)
抗原
See all CCBP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CCBP2 Antibody detects endogenous levels of total CCBP2.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CCBP2, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Chemokine Binding Protein 2 (CCBP2) (AA 1-384) antibody
CCBP2 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (N-Term) antibodyCCBP2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (N-Term) antibodyCCBP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 298-328), (C-Term) antibodyCCBP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2838 unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (C-Term) antibodyCCBP2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 335-384) antibodyCCBP2 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 54-84) antibodyCCBP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4519 unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (N-Term) antibodyCCBP2 适用: 人, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 335-384) antibodyCCBP2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (C-Term) antibodyCCBP2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CCBP2 (Chemokine Binding Protein 2 (CCBP2))
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别名
- ACKR2
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背景
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Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Gene: ACKR2
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分子量
- 34 kDa
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基因ID
- 1238
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UniProt
- O00590
抗原
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