C1QBP 抗体 (Internal Region)
Quick Overview for C1QBP 抗体 (Internal Region) (ABIN6256975)
抗原
See all C1QBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- C1QBP Antibody detects endogenous levels of total C1QBP.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human C1QBP, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 76-282) antibody
C1QBP 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) antibodyC1QBP 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 76-282) antibodyC1QBP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 71-278) antibodyC1QBP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 1-282) antibodyC1QBP 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 74-282) antibodyC1QBP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 71-278) antibodyC1QBP 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 190-282) antibodyC1QBP 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 173-282) antibodyC1QBP 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) antibodyC1QBP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))
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别名
- C1QBP
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背景
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Description: Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q, specifically binds to the globular "heads" of C1q thus inhibiting C1, may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes, the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process, the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response, ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection.
Gene: C1QBP
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分子量
- 32 kDa
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基因ID
- 708
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UniProt
- Q07021
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途径
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
抗原
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