ATF5 抗体 (N-Term)
Quick Overview for ATF5 抗体 (N-Term) (ABIN6256928)
抗原
See all ATF5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- ATF5 Antibody detects endogenous levels of total ATF5.
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预测反应
- Pig,Bovine,Horse,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ATF5, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Activating Transcription Factor 5 (ATF5) antibody
ATF5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (AA 101-200) antibodyATF5 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4G5 unconjugated
anti-Activating Transcription Factor 5 (ATF5) (N-Term) antibodyATF5 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (acLys29) antibodyATF5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (AA 1-282) antibodyATF5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) antibodyATF5 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 9D8 unconjugated Recombinant Antibody
anti-Activating Transcription Factor 5 (ATF5) (AA 101-150) antibodyATF5 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (C-Term) antibodyVerified ATF5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (acLys29) antibodyATF5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (C-Term) antibodyATF5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- ATF5 (Activating Transcription Factor 5 (ATF5))
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别名
- ATF5
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背景
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Description: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
Gene: ATF5
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分子量
- 31 kDa
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基因ID
- 22809
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UniProt
- Q9Y2D1
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途径
- Myometrial Relaxation and Contraction
抗原
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