JAML 抗体 (C-Term)
Quick Overview for JAML 抗体 (C-Term) (ABIN6256833)
抗原
See all JAML (AMICA1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- JAML1 Antibody detects endogenous levels of total JAML1.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human JAML1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1) antibody
AMICA1 适用: 小鼠 FACS, IP 宿主: 仓鼠 Monoclonal 4E10 unconjugated
anti-Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1) (AA 1-355) antibodyAMICA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))
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别名
- JAML
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背景
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Description: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Gene: JAML
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基因ID
- 120425
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UniProt
- Q86YT9
抗原
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