WNK1 抗体 (pThr60)
Quick Overview for WNK1 抗体 (pThr60) (ABIN6256585)
抗原
See all WNK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr60
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特异性
- Phospho-WNK1 (Thr60) Antibody detects endogenous levels of WNK1 only when phosphorylated at Threonine 60.
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预测反应
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human WNK1 around the phosphorylation site of Thr60.
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亚型
- IgG
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anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1-207) antibody
WNK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (N-Term) antibodyWNK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1154-1195), (Middle Region) antibodyWNK1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1954-2231) antibodyWNK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (C-Term) antibodyWNK1 适用: 人, 小鼠, 大鼠, 马, 猴, 兔, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (Internal Region) antibodyWNK1 适用: 人, 小鼠, 大鼠, 马, 猴, 兔, Pig, Bat, Hamster, 小鸡, Cow ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1-210) antibodyWNK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (pThr60) antibodyWNK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1848-1882) antibodyWNK1 适用: 人 WB 宿主: 兔 Polyclonal RB56242 unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (Tyr773) antibodyWNK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))
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别名
- WNK1
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背景
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Description: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Gene: WNK1
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分子量
- 230kDa
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基因ID
- 65125
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UniProt
- Q9H4A3
抗原
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