SF3B1 抗体 (pThr313)
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北京 101111
Quick Overview for SF3B1 抗体 (pThr313) (ABIN6256541)
抗原
See all SF3B1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr313
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特异性
- Phospho-SF3B1 (Thr313) Antibody detects endogenous levels of SF3B1.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human SF3B1 around the phosphorylation site of Thr313.
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
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别名
- SF3B1
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背景
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Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
Gene: SF3B1
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分子量
- 155kDa
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基因ID
- 23451
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UniProt
- O75533
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途径
- Chromatin Binding
抗原
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