HDAC3 抗体 (pSer424)
Quick Overview for HDAC3 抗体 (pSer424) (ABIN6256332)
抗原
See all HDAC3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer424
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特异性
- Phospho-HDAC3 (Ser424) Antibody detects endogenous levels of HDAC3 only when phosphorylated at Serine 424.
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预测反应
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human HDAC3 around the phosphorylation site of Ser424.
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亚型
- IgG
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anti-Histone Deacetylase 3 (HDAC3) (AA 299-428) antibody
HDAC3 适用: 人 WB, IHC, IF, IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (C-Term) antibodyHDAC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 1-428) antibodyHDAC3 适用: 人 WB, ELISA, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 319-428) antibodyHDAC3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-Histone Deacetylase 3 (HDAC3) antibodyHDAC3 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (C-Term) antibodyHDAC3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 1-428) antibodyHDAC3 适用: 人 ELISA, IF, IP 宿主: 小鼠 Monoclonal 2F9-4B7 unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 31-130) antibodyHDAC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) antibodyHDAC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 4D4 unconjugated Recombinant Antibody
anti-Histone Deacetylase 3 (HDAC3) (AA 224-428) antibodyHDAC3 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 7G6C5 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- HDAC3 (Histone Deacetylase 3 (HDAC3))
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别名
- HDAC3
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背景
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Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Gene: HDAC3
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分子量
- 48kDa
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基因ID
- 8841
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UniProt
- O15379
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途径
- Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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