MAPKAP1 抗体 (pThr86)
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北京 101111
Quick Overview for MAPKAP1 抗体 (pThr86) (ABIN6255748)
抗原
See all MAPKAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr86
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特异性
- Phospho-Sin1 (Thr86) Antibody detects endogenous levels of Sin1.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human Sin1 around the phosphorylation site of Thr86.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 8-236) antibody
MAPKAP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (C-Term) antibodyMAPKAP1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 100-150) antibodyMAPKAP1 适用: 人, 小鼠, 大鼠, 犬, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 370-486) antibodyMAPKAP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 85-102) antibodyMAPKAP1 适用: 人, 小鼠, 大鼠, 犬, Cow, 小鸡, 马, 绵羊, Bat, 猴, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 1-290) antibodyMAPKAP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (C-Term) antibodyMAPKAP1 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))
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别名
- Sin1
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背景
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Description: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Gene: MAPKAP1
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分子量
- 78, 74kDa
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基因ID
- 79109
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UniProt
- Q9BPZ7
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途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events
抗原
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