Smad2/3 抗体 (pThr8, Thr8)
Quick Overview for Smad2/3 抗体 (pThr8, Thr8) (ABIN6255740)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr8, Thr8
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特异性
- Phospho-Smad2/3 (Thr8) Antibody detects endogenous levels of Smad2/3 only when phosphorylated at Threonine 8
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human Smad2/3 around the phosphorylation site of Threonine 8
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亚型
- IgG
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anti-Smad2/3 Transcription Factor (SMAD2/3) (AA 30-80) antibody
SMAD2/3 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Smad2/3 Transcription Factor (SMAD2/3) (pThr8) antibodySMAD2/3 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Smad2/3 Transcription Factor (SMAD2/3) (Ser104) antibodySMAD2/3 适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Smad2/3 Transcription Factor (SMAD2/3) (AA 1-50) antibodySMAD2/3 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Smad2/3 Transcription Factor (SMAD2/3) (N-Term) antibodySMAD2/3 适用: 人, 大鼠, 小鸡, Cow, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000 IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))
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别名
- Smad2/3
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背景
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Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Gene: SMAD3
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分子量
- 48/60kDa
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基因ID
- 4088
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UniProt
- P84022, Q15796
抗原
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