GRB10 抗体 (pSer476)
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北京 101111
Quick Overview for GRB10 抗体 (pSer476) (ABIN6255368)
抗原
See all GRB10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer476
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特异性
- Phospho-GRB10 (Ser476) Antibody detects endogenous levels of GRB10.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human GRB10 around the phosphorylation site of Ser476.
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 392-594) antibody
GRB10 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 61-150) antibodyGRB10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 15-180) antibodyGRB10 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 100-150) antibodyGRB10 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-100) antibodyGRB10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-30), (N-Term) antibodyGRB10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (Ser428) antibodyGRB10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-251) antibodyGRB10 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 1-276) antibodyGRB10 适用: 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 10 (GRB10) (AA 33-82) antibodyGRB10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))
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别名
- GRB10
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背景
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Description: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Gene: GRB10
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分子量
- 80kDa
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基因ID
- 2887
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UniProt
- Q13322
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途径
- Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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