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FOXO1 抗体 (pSer256)

Name: FOXO1 抗体 (pSer256)
SKU: ABIN6255137
Availability: OutOfStock

This anti-FOXO1 antibody is a 兔多克隆 antibody detecting FOXO1 in WB, IHC, ELISA, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of FKHR phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (FOXO1 抗体 (pSer256))

ABIN6267626 at 1/100 staining human colon carcinoma tissue sections by IHC-P. (FOXO1 抗体 (pSer256))

IHC

IF/ICC

Western blot analysis of Phospho-FKHR (Ser256) expression in various lysates (FOXO1 抗体 (pSer256))

4 images

产品编号 ABIN6255137

发货至: 中国

Datasheet as PDF

Quick Overview for FOXO1 抗体 (pSer256) (ABIN6255137)

抗原

See all FOXO1 抗体

FOXO1 (Forkhead Box O1 (FOXO1))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This FOXO1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product FOXO1 Primary Antibody

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pSer256

特异性

Phospho-FOXO1A (Ser256) Antibody detects endogenous levels of FOXO1A only when phosphorylated at Serine 256.

预测反应

Pig,Bovine,Dog,Chicken,Xenopus

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human FOXO1A around the phosphorylation site of Ser256.

亚型

IgG
anti-Forkhead Box O1 (FOXO1) (AA 165-270) antibody
FOXO1 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 小鸡 WB, ELISA, IF (p), IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box O1 (FOXO1) (AA 333-557) antibody
FOXO1 适用: 人 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box O1 (FOXO1) antibody
FOXO1 适用: 人, 小鼠 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3B6 unconjugated

anti-Forkhead Box O1 (FOXO1) antibody
FOXO1 适用: 人 WB, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 3B6 unconjugated

anti-Forkhead Box O1 (FOXO1) antibody
FOXO1 适用: 人, 小鼠 WB, IHC, ELISA, IF/ICC 宿主: 小鼠 Monoclonal unconjugated

anti-Forkhead Box O1 (FOXO1) (AA 556-655) antibody
FOXO1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4E9 unconjugated

anti-Forkhead Box O1 (FOXO1) (AA 452-555) antibody
FOXO1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A10 unconjugated

anti-Forkhead Box O1 (FOXO1) antibody
FOXO1 适用: 人, 小鼠 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 3B6 unconjugated

anti-Forkhead Box O1 (FOXO1) (AA 222-469) antibody
FOXO1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box O1 (FOXO1) (AA 1-300) antibody
FOXO1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

FOXO1 (Forkhead Box O1 (FOXO1))

别名

FOXO1

背景

Description: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).
Gene: FOXO1

分子量

69kDa

基因ID

2308

UniProt

Q12778

途径

PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling