Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT
Optimal dilution of the PSGL-1 antibody should be determined by the researcher.
限制
仅限研究用
状态
Liquid
浓度
0.2 mg/mL
缓冲液
PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Aliquot and Store at -20C. Avoid freez-thaw cycles.
抗原
SELPLG
(Selectin P Ligand (SELPLG))
别名
CD162
背景
P selectin glycoprotein ligand 1 (PSGL-1), also called CD162 glycoprotein, functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.