SRGAP2 抗体 (C-Term)
Quick Overview for SRGAP2 抗体 (C-Term) (ABIN6244084)
抗原
See all SRGAP2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 997-1030, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 997-1030 amino acids from the C-terminal region of human SRGAP2.
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亚型
- Ig Fraction
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anti-SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) antibody
SRGAP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) (AA 1040-1071), (C-Term) antibodySRGAP2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB53245 unconjugated
anti-SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) (Internal Region) antibodyVerified SRGAP2 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))
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别名
- SRGAP2
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背景
- RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
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分子量
- 120871
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UniProt
- O75044
抗原
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