RBMX 抗体 (AA 222-252)
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北京 101111
Quick Overview for RBMX 抗体 (AA 222-252) (ABIN6244062)
抗原
See all RBMX 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 222-252
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This RBMX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the Central region of human RBMX.
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亚型
- Ig Fraction
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应用备注
- WB: 1:2000. WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- RBMX (RNA Binding Motif Protein, X-Linked (RBMX))
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别名
- RBMX
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背景
- RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter, may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion, acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation, probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways, promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
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分子量
- 42332
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UniProt
- P38159
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途径
- Chromatin Binding, Ribonucleoprotein Complex Subunit Organization
抗原
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