R-Spondin 3 抗体 (AA 197-230)
Quick Overview for R-Spondin 3 抗体 (AA 197-230) (ABIN6243984)
抗原
See all R-Spondin 3 (RSPO3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 197-230
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This RSPO3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 197-230 amino acids from human RSPO3.
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亚型
- Ig Fraction
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anti-R-Spondin 3 (RSPO3) (AA 22-272) antibody
RSPO3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 3 (RSPO3) (AA 22-272) antibodyRSPO3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 3 (RSPO3) (AA 214-248) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal RB54573 unconjugated
anti-R-Spondin 3 (RSPO3) (AA 202-251) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 3 (RSPO3) (AA 1-100) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:8000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- R-Spondin 3 (RSPO3)
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别名
- RSPO3
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背景
- Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.
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分子量
- 30929
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UniProt
- Q9BXY4
抗原
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