PLK4 抗体 (AA 724-758)
Quick Overview for PLK4 抗体 (AA 724-758) (ABIN6243950)
抗原
See all PLK4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 724-758
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This PLK4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 724-758 amino acids from the region of human PLK4.
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亚型
- Ig Fraction
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anti-Polo-Like Kinase 4 (PLK4) (AA 1-110) antibody
PLK4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Polo-Like Kinase 4 (PLK4) antibodyPLK4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-970) antibodyPLK4 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-970) antibodyPLK4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 641-970) antibodyPLK4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- PLK4 (Polo-Like Kinase 4 (PLK4))
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别名
- PLK4
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物质类
- Phage Protein
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背景
- Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.
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分子量
- 108972
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UniProt
- O00444
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途径
- M Phase
抗原
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