TPR 抗体 (C-Term)
Quick Overview for TPR 抗体 (C-Term) (ABIN6243923)
抗原
See all TPR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2026-2060, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This TPR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2026-2060 amino acids from the C-terminal region of human TPR.
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亚型
- Ig Fraction
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anti-Nucleoprotein TPR (TPR) (AA 1-98) antibody
TPR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Nucleoprotein TPR (TPR) (AA 1-98) antibodyTPR 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F8 unconjugated
anti-Nucleoprotein TPR (TPR) (AA 2034-2083) antibodyTPR 适用: 人, Cow, 犬, 兔, 豚鼠, 马, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Nucleoprotein TPR (TPR) antibodyTPR 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nucleoprotein TPR (TPR) (AA 2276-2325) antibodyTPR 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- TPR (Nucleoprotein TPR (TPR))
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别名
- TPR
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背景
- Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus, in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters, associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:< a href="http://www.uniprot.org/citations/22253824" target="_blank">22253824 and PubMed:< a href="http://www.uniprot.org/citations/11952838" target="_blank">11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution, involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.
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分子量
- 267293
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UniProt
- P12270
抗原
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