CHMP4A 抗体 (C-Term)
Quick Overview for CHMP4A 抗体 (C-Term) (ABIN6243822)
抗原
See all CHMP4A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 205-239, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This CHMP4A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of human CHMP4A.
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亚型
- Ig Fraction
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anti-Charged Multivesicular Body Protein 4A (CHMP4A) (AA 1-222) antibody
CHMP4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4A (CHMP4A) (C-Term) antibodyCHMP4A 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4A (CHMP4A) (C-Term) antibodyCHMP4A 适用: 人, Cow, 兔, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- CHMP4A (Charged Multivesicular Body Protein 4A (CHMP4A))
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别名
- CHMP4A
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背景
- Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
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分子量
- 25098
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UniProt
- Q9BY43
抗原
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