Chemerin 抗体 (AA 1-35)
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北京 101111
Quick Overview for Chemerin 抗体 (AA 1-35) (ABIN6243636)
抗原
See all Chemerin (RARRES2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-35
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This RARRES2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 01-35 amino acids from human RARRES2.
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亚型
- Ig Fraction
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anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 17-163) antibody
RARRES2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 81-163) antibodyRARRES2 适用: 人, 大鼠, 小鼠, 兔 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 21-157) antibodyRARRES2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-163) antibodyRARRES2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 89-133) antibodyRARRES2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB56709 unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 21-155) antibodyRARRES2 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-163) antibodyRARRES2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 17-163) antibodyCell Culture Grade RARRES2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G2 unconjugated
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应用备注
- IF: 1:25. WB: 1:2000. FC: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))
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别名
- RARRES2
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背景
- Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity- related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
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分子量
- 18618
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UniProt
- Q99969
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途径
- Brown Fat Cell Differentiation
抗原
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