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Chemerin 抗体 (AA 89-133)

This anti-Chemerin antibody is a 兔 多克隆 antibody detecting Chemerin in WB 和 FACS. Suitable for 人.
产品编号 ABIN6243635
发货至: 中国

Quick Overview for Chemerin 抗体 (AA 89-133) (ABIN6243635)

抗原

See all Chemerin (RARRES2) 抗体
Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

适用

  • 35
  • 35
  • 23
  • 15

宿主

  • 47
  • 7
  • 5

克隆类型

  • 49
  • 10
多克隆

标记

  • 23
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This Chemerin antibody is un-conjugated

应用范围

  • 50
  • 26
  • 26
  • 19
  • 8
  • 6
  • 6
  • 4
  • 4
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Flow Cytometry (FACS)

克隆位点

RB56709
  • 抗原表位

    • 15
    • 15
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 89-133

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This RARRES2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 89-133 amino acids from the Central region of human RARRES2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:2000. FC: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

    别名

    RARRES2

    背景

    Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity- related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.

    分子量

    18618

    UniProt

    Q99969

    途径

    Brown Fat Cell Differentiation
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