CHMP3 抗体 (N-Term)
This anti-CHMP3 antibody is a 兔 多克隆 antibody detecting CHMP3 in WB. Suitable for 人 和 小鼠.
Quick Overview for CHMP3 抗体 (N-Term) (ABIN6243582)
抗原
See all CHMP3 抗体
CHMP3
(Charged Multivesicular Body Protein 3 (CHMP3))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This CHMP3 antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
RB51722
-
-
抗原表位
- AA 28-61, N-Term
-
预测反应
- B, Pr, Rat
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This CHMP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 28-61 amino acids from the N-terminal region of human CHMP3.
-
亚型
- Ig Fraction
-
-
anti-Charged Multivesicular Body Protein 3 (CHMP3) (AA 28-77) antibody
CHMP3 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 3 (CHMP3) antibodyCHMP3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
-
-
应用备注
- WB: 1:1000. WB: 1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
有效期
- 6 months
-
-
- CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))
-
别名
- CHMP3
-
背景
- Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
-
分子量
- 25073
-
UniProt
- Q9Y3E7
抗原
-
You are here:
