RNF126 抗体 (AA 84-115)
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北京 101111
Quick Overview for RNF126 抗体 (AA 84-115) (ABIN6243426)
抗原
See all RNF126 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 84-115
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This RNF126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-115 amino acids from the Central region of human RNF126.
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亚型
- Ig Fraction
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anti-Ring Finger Protein 126 (RNF126) (AA 39-225) antibody
RNF126 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 126 (RNF126) (AA 1-326) antibodyRNF126 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F11 unconjugated
anti-Ring Finger Protein 126 (RNF126) (AA 51-150) antibodyRNF126 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 126 (RNF126) (AA 71-120) antibodyRNF126 适用: 人, 小鼠, 大鼠, 犬, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 126 (RNF126) (N-Term) antibodyRNF126 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 126 (RNF126) (N-Term) antibodyRNF126 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- RNF126 (Ring Finger Protein 126 (RNF126))
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别名
- RNF126
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背景
- E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:< a href="http://www.uniprot.org/citations/24981174" target="_blank">24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:< a href="http://www.uniprot.org/citations/24275455" target="_blank">24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:< a href="http://www.uniprot.org/citations/23026136" target="_blank">23026136). May monoubiquitinate AICDA (PubMed:< a href="http://www.uniprot.org/citations/23277564" target="_blank">23277564).
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分子量
- 33861
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UniProt
- Q9BV68
抗原
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