MLL2 抗体 (C-Term)
(3 references)Quick Overview for MLL2 抗体 (C-Term) (ABIN6243263)
抗原
See all MLL2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 4980-5009, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This MLL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4980-5009 amino acids from the C-terminal region of human MLL2.
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亚型
- Ig Fraction
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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) (AA 2-14) antibody
MLL2 适用: 人 ELISA, IHC (p), IHC 宿主: 山羊 Polyclonal unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) (AA 1487-1586) antibodyMLL2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) (AA 1487-1587) antibodyMLL2 适用: 人 ELISA, WB, IHC (p), IHC 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) (AA 4980-5009) antibodyMLL2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:80000. WB: 1:27000. IHC-P-Leica: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells." in: Cancer research, Vol. 74, Issue 6, pp. 1705-17, (2014) (PubMed).
: "Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo." in: The Journal of steroid biochemistry and molecular biology, Vol. 141, pp. 160-70, (2014) (PubMed).
: "Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4." in: Genes & development, Vol. 26, Issue 24, pp. 2749-62, (2012) (PubMed).
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: "UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells." in: Cancer research, Vol. 74, Issue 6, pp. 1705-17, (2014) (PubMed).
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- MLL2 (Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2))
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别名
- MLL2
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背景
- The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL2. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. The gene for MLL2 encodes a 5,262-amino acid protein containing a SET domain, 5 PHD fingers, potential zinc fingers, and a long run of glutamines interrupted by hydrophobic residues (mostly leucine). They also detected an alternatively spliced form encoding 4,957 amino acids and lacking an N-terminal zinc finger and PHD finger. By analysis of rodent/human hybrid cells and analysis of the Genebridge radiation hybrid panel, they mapped the gene to the 12p13.1-qter region. The 12q12-q13 region is involved in duplications and translocations associated with cancer. By database searching, Karlin et al. (2002) identified 192 human protein sequences that have multiple amino acid runs, many of which are associated with disease, including cancer. Karlin et al. (2002) found that a key aspect of 82 of these protein sequences is their role in transcription, translation, and developmental regulation. MLL2 is a striking example of proteins with multiple amino acid runs, with 22 glutamine runsGenes encoding a significant number of long amino acid runs are potentially associated with diseases, such as cancer.
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分子量
- 593389
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NCBI登录号
- NP_003473
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UniProt
- O14686
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Warburg Effect
抗原
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