GPR56 抗体
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北京 101111
Quick Overview for GPR56 抗体 (ABIN6243208)
抗原
See all GPR56 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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免疫原
- This antibody is generated from a mouse immunized with a recombinant protein.
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亚型
- IgG1 kappa
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- GPR56 (G Protein-Coupled Receptor 56 (GPR56))
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别名
- GPR56
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背景
- Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA, unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
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分子量
- 77738
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UniProt
- Q9Y653
抗原
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