GPR56
适用: 人
WB, ELISA, IF
宿主: 兔
Polyclonal
unconjugated
应用备注
WB: 1:2000
限制
仅限研究用
状态
Liquid
储存条件
4 °C,-20 °C
有效期
6 months
抗原
GPR56
(G Protein-Coupled Receptor 56 (GPR56))
别名
GPR56
背景
Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA, unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.