Dynamin 1-Like 抗体 (C-Term)
Quick Overview for Dynamin 1-Like 抗体 (C-Term) (ABIN6243175)
抗原
See all Dynamin 1-Like (DNM1L) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 513-547, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This DNM1L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DNM1L.
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亚型
- Ig Fraction
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应用备注
- WB: 1:8000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- Dynamin 1-Like (DNM1L)
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别名
- DNM1L
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背景
- Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.
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分子量
- 81877
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UniProt
- O00429
抗原
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