CYR61 抗体 (AA 143-174)
Our Local Distributor
北京 101111
Quick Overview for CYR61 抗体 (AA 143-174) (ABIN6243134)
抗原
See all CYR61 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 143-174
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This CYR61 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-174 amino acids from the Central region of human CYR61.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- WB: 1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
有效期
- 6 months
-
-
- CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
-
别名
- CYR61
-
背景
- Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
-
分子量
- 42027
-
UniProt
- O00622
-
途径
- Positive Regulation of Endopeptidase Activity, Growth Factor Binding
抗原
-