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EHMT2 抗体 (AA 361-395)

This 兔 多克隆 antibody specifically detects EHMT2 in WB. It exhibits reactivity toward 人.
产品编号 ABIN6243050
发货至: 中国
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Quick Overview for EHMT2 抗体 (AA 361-395) (ABIN6243050)

抗原

See all EHMT2 抗体
EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

适用

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宿主

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克隆类型

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多克隆

标记

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This EHMT2 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB51566
  • 抗原表位

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    AA 361-395

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This EHMT2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 361-395 amino acids from the Central region of human EHMT2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

    别名

    EHMT2

    背景

    Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

    分子量

    132370

    UniProt

    Q96KQ7
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