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EHMT2 抗体 (AA 589-623)

This anti-EHMT2 antibody is a 兔 多克隆 antibody detecting EHMT2 in WB. Suitable for 小鼠.
产品编号 ABIN6243048
发货至: 中国

Quick Overview for EHMT2 抗体 (AA 589-623) (ABIN6243048)

抗原

See all EHMT2 抗体
EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

适用

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小鼠

宿主

  • 46
  • 2
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克隆类型

  • 39
  • 10
多克隆

标记

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This EHMT2 antibody is un-conjugated

应用范围

  • 39
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Western Blotting (WB)

克隆位点

RB52371
  • 抗原表位

    • 8
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    AA 589-623

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This Mouse Ehmt2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 589-623 amino acids from the Central region of Mouse Ehmt2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

    别名

    Ehmt2

    背景

    Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

    分子量

    138039

    UniProt

    Q9Z148
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