RUNX1 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for RUNX1 抗体 (C-Term) (ABIN6243043)
抗原
See all RUNX1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 426-459, C-Term
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This Mouse Runx1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 426-459 amino acids from the C-terminal region of Mouse Runx1.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- WB: 1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
有效期
- 6 months
-
-
- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
-
别名
- Runx1
-
背景
- CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B- dependent transcriptional activation (By similarity).
-
分子量
- 48610
-
UniProt
- Q03347
抗原
-