SREBF chaperone 抗体 (N-Term)
Quick Overview for SREBF chaperone 抗体 (N-Term) (ABIN6243003)
抗原
See all SREBF chaperone (SCAP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 49-83, N-Term
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP.
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亚型
- IgG1 kappa
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anti-SREBF chaperone (SCAP) (AA 604-632) antibody
SCAP 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22508 unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP 适用: 人 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-SREBF chaperone (SCAP) (AA 977-1194) antibodySCAP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:4000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- SREBF chaperone (SCAP)
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别名
- SCAP
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背景
- Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
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分子量
- 139729
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UniProt
- Q12770
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途径
- SARS-CoV-2 Protein Interactome
抗原
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