WNK1 抗体 (AA 1848-1882)
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北京 101111
Quick Overview for WNK1 抗体 (AA 1848-1882) (ABIN6242959)
抗原
See all WNK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1848-1882
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This WNK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1848-1882 amino acids from human WNK1.
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亚型
- IgG
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))
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别名
- WNK1
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背景
- Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
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分子量
- 250794
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UniProt
- Q9H4A3
抗原
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