SLUG 抗体 (AA 98-129)
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北京 101111
Quick Overview for SLUG 抗体 (AA 98-129) (ABIN6242822)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 98-129
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预测反应
- B
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-129 amino acids from the Central region of human SLUG.
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亚型
- Ig Fraction
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anti-SLUG (AA 5-120) antibody
适用: 人, 大鼠, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SLUG antibody适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SLUG (AA 1-30), (N-Term) antibody适用: 人 WB 宿主: 兔 Polyclonal RB15389 unconjugated
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应用备注
- IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." in: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).
: "Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion." in: Cancer research, Vol. 73, Issue 1, pp. 235-45, (2013) (PubMed).
: "Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma." in: Histopathology, Vol. 62, Issue 2, pp. 326-33, (2012) (PubMed).
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: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." in: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).
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- SLUG
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背景
- SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.
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分子量
- 29986
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NCBI登录号
- NP_003059
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UniProt
- O43623
抗原
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