ECT2 抗体 (AA 200-460)
Quick Overview for ECT2 抗体 (AA 200-460) (ABIN6242298)
抗原
See all ECT2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-460
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This ECT2 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 200-460 amino acids from human ECT2.
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亚型
- IgG1 kappa
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anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 283-453) antibody
ECT2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (N-Term) antibodyVerified ECT2 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 453-647) antibodyECT2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 166-348) antibodyECT2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 781-883) antibodyECT2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 46-145) antibodyECT2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D4 unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) antibodyECT2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 551-600) antibodyECT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, 斑马鱼, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 580-629) antibodyECT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (N-Term) antibodyECT2 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
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别名
- ECT2
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背景
- Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)- induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
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分子量
- 103505
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UniProt
- Q9H8V3
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途径
- Neurotrophin Signaling Pathway, Cell-Cell Junction Organization
抗原
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