DPPA3 抗体 (C-Term)
Quick Overview for DPPA3 抗体 (C-Term) (ABIN6242290)
抗原
See all DPPA3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 145-179, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This DPPA3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-179 amino acids from the C-terminal region of human DPPA3.
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亚型
- Ig Fraction
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anti-Developmental Pluripotency Associated 3 (DPPA3) (AA 101-159) antibody
DPPA3 适用: 小鼠, Pig WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Developmental Pluripotency Associated 3 (DPPA3) (AA 1-159) antibodyDPPA3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Developmental Pluripotency Associated 3 (DPPA3) (AA 1-159) antibodyDPPA3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Developmental Pluripotency Associated 3 (DPPA3) (AA 134-170), (C-Term) antibodyDPPA3 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51138 unconjugated
anti-Developmental Pluripotency Associated 3 (DPPA3) (AA 1-159) antibodyDPPA3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Developmental Pluripotency Associated 3 (DPPA3) (AA 100-150) antibodyDPPA3 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
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别名
- DPPA3
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背景
- Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).
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分子量
- 17851
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UniProt
- Q6W0C5
抗原
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