CHD5 抗体 (AA 64-98)
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北京 101111
Quick Overview for CHD5 抗体 (AA 64-98) (ABIN6242241)
抗原
See all CHD5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 64-98
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This CHD5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 64-98 amino acids from human CHD5.
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亚型
- Ig Fraction
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anti-Chromodomain Helicase DNA Binding Protein 5 (CHD5) (AA 1600-1699) antibody
CHD5 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Helicase DNA Binding Protein 5 (CHD5) (C-Term) antibodyCHD5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Helicase DNA Binding Protein 5 (CHD5) (Internal Region) antibodyVerified CHD5 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Chromodomain Helicase DNA Binding Protein 5 (CHD5) (C-Term) antibodyCHD5 适用: 人, 小鼠 WB, ICC, IF 宿主: 大鼠 Monoclonal 5A10 unconjugated
anti-Chromodomain Helicase DNA Binding Protein 5 (CHD5) (AA 712-896) antibodyCHD5 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
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别名
- CHD5
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背景
- Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
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分子量
- 223050
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UniProt
- Q8TDI0
抗原
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