LSD1 抗体
Quick Overview for LSD1 抗体 (ABIN6241814)
抗原
See all LSD1 (KDM1A) 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- Recombinant Protein
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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibody
KDM1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibodyKO Validated KDM1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibodyKDM1A 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9D2 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 709-876) antibodyKDM1A 适用: 人, 小鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 1H2F8 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibodyKDM1A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142) antibodyKDM1A 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibodyKDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852), (C-Term) antibodyKDM1A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7583 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibodyKDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibodyKDM1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 1G7 unconjugated Recombinant Antibody
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应用备注
- IP: 1:500. WB: 1:1000. ICC: 1:100
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
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别名
- KDM1/LSD1
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背景
- Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E- cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
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UniProt
- O60341
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途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect
抗原
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