PRKAB1 抗体
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北京 101111
Quick Overview for PRKAB1 抗体 (ABIN6241589)
抗原
See all PRKAB1 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- Recombinant Protein
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应用备注
- IP: 1:500. WB: 1:1000. IHC: 1:100. ICC: 1:100
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))
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别名
- AMPK beta 1
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背景
- Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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UniProt
- Q9Y478
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途径
- AMPK Signaling, Warburg Effect
抗原
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