Protein Phosphatase 4C 抗体
This 小鼠 单克隆 antibody specifically detects Protein Phosphatase 4C in WB, ICC 和 IHC. It exhibits reactivity toward 人.
产品编号 ABIN6241238
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for Protein Phosphatase 4C 抗体 (ABIN6241238)
抗原
Protein Phosphatase 4C
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
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免疫原
- Recombinant Protein
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应用备注
- WB: 1:200. IHC: 1:100. ICC: 1:200
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- Protein Phosphatase 4C
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背景
- Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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UniProt
- P60510
抗原
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