DBC1 抗体
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北京 101111
Quick Overview for DBC1 抗体 (ABIN6241147)
抗原
See all DBC1 (BRINP1) 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- Recombinant Protein
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anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 101-200) antibody
BRINP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 20-320) antibodyBRINP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 1-320) antibodyBRINP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 1-320) antibodyBRINP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 662-761) antibodyBRINP1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- IP: 1:500. WB: 1:500. ICC: 1:200
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))
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别名
- DBC1
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背景
- Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.
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UniProt
- Q8N163
抗原
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